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Updated: May 15, 2026

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
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Published on: May 30, 2011

Pain response measured with arterial spin labeling.

Nasim Maleki1, Jennifer Brawn, Gabi Barmettler

  • 1P.A.I.N. Group, Department of Anesthesia, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. nasim.maleki@childrens.harvard.edu

NMR in Biomedicine
|January 16, 2013
PubMed
Summary

Pulsed-continuous arterial spin labeling (pCASL) reliably detects brain responses to pain, offering an alternative to BOLD imaging. This method is valuable for functional MRI pain studies, especially when blood flow is compromised.

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...