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Harry Lee Parker and paroxysmal dysarthria and ataxia

James P Klaas1, David B Burkholder, Wolfgang Singer

  • 1Mayo Clinic, Rochester, MN, USA.

Neurology
|January 16, 2013
PubMed
Abstract

Insights

Parker

Area of Science:

  • Neurology
  • Neuroscience

Background:

  • Review of historical descriptions of paroxysmal dysarthria and ataxia in multiple sclerosis (MS).
  • Focus on Parker's 1946 case series, which identified six MS patients with these symptoms.

Discussion:

  • The term "paroxysmal dysarthria and ataxia" was coined in 1959.
  • This phenomenon is now recognized as a manifestation of MS.

Key Insights:

  • Parker's 1946 publication was the first accurate description of paroxysmal dysarthria and ataxia in MS patients.
  • Lesions in the midbrain, near the red nucleus, are implicated in recent reports.

Outlook:

  • Further research into the precise neuroanatomical correlates of paroxysmal dysarthria and ataxia in MS.
  • Understanding the pathophysiology may lead to improved diagnostic and therapeutic strategies for MS.

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