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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
A first look at chorioamnionitis management practice variation among US obstetricians
Mara B Greenberg1, Britta L Anderson, Jay Schulkin
1Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Lucile Packard Children's Hospital at Stanford, Stanford University, 300 Pasteur Drive HH333, Stanford, CA 94305, USA. mbgreenberg@yahoo.com
US obstetricians show significant variation in diagnosing and treating chorioamnionitis. Current clinical practices lack uniformity, highlighting a need for evidence-based guidelines to improve patient care.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases in Pregnancy
- Clinical Practice Patterns
Background:
- Chorioamnionitis is a common intra-amniotic infection.
- Standardized diagnostic and treatment protocols are lacking.
- Variability in clinical practice may impact patient outcomes.
Purpose of the Study:
- To investigate current diagnostic and treatment practices for chorioamnionitis among US obstetricians.
- To identify factors influencing management strategies for chorioamnionitis.
- To assess the extent of variation in chorioamnionitis care.
Main Methods:
- A mail-based survey was distributed to members of the American College of Obstetricians and Gynecologists.
- The survey queried demographics, practice setting, and chorioamnionitis management.
- Univariable and multivariable analyses were performed on returned surveys.
Main Results:
- A 53.8% response rate was achieved, with 212 surveys analyzed.
- Most respondents practice in group settings, manage over 100 deliveries annually, and have >10 years of experience.
- Significant variation exists in diagnostic criteria, antibiotic regimens, and postpartum treatment duration.
Conclusions:
- Contemporary clinical practices for chorioamnionitis diagnosis and treatment exhibit wide variation.
- This variability may stem from a lack of high-level evidence.
- Future clinical trials are needed to establish evidence-based recommendations for chorioamnionitis management.
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