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Related Concept Videos

Masonry Curtain Walls01:20

Masonry Curtain Walls

Masonry curtain walls employ brick or stone veneers supported by the building's structure to form an external cladding system that is both aesthetically appealing and functional. These walls are erected through two principal techniques, first by traditional layering of masonry units and second by using prefabricated panels. Traditional construction relies on steel shelf angles attached to the spandrel beam for support, with high-bond mortars ensuring secure attachment of masonry veneer units.
Free-falling Bodies: Introduction01:07

Free-falling Bodies: Introduction

All objects, neglecting air resistance, fall with the same acceleration towards the Earth's center due to the force exerted by the Earth's gravity. This experimentally determined fact is unexpected because we are so accustomed to the effects of air resistance and friction that we expect light objects to fall slower than heavier ones. People believed that a heavier object had a greater acceleration when falling until Galileo Galilei (1564–1642) proved otherwise. We now know this is not the case.
Expansion and Contraction in Masonry Walls01:19

Expansion and Contraction in Masonry Walls

Masonry walls are subject to slight expansion and contraction due to variations in temperature and moisture. Thermal movement in masonry is relatively straightforward to measure and plan for. On the other hand, moisture movement poses more of a challenge. New clay masonry units typically absorb water and expand over time under normal environmental conditions. Conversely, new concrete masonry units tend to shrink as they lose the excess moisture acquired during their production process.
To...
Masonry Loadbearing Walls01:16

Masonry Loadbearing Walls

Masonry load-bearing walls, constructed from materials like brick, stone, or concrete masonry units, serve as a crucial component in building structures by supporting the loads from floors and roofs and transferring them to the foundation. These walls, known for their compressive strength, can be reinforced or unreinforced to suit different building needs, accommodating both the dead and live loads while maintaining safety through lower working stresses compared to the materials' ultimate...
Laying Concrete Masonry01:16

Laying Concrete Masonry

Constructing a concrete masonry wall involves a series of steps designed to ensure durability, stability, and alignment. The construction starts with preparing the base, which includes cleaning the area where the wall will be erected. The next step involves spreading mortar where the first row of concrete blocks will be laid, typically starting at a corner section to help define the wall's boundaries.
Mortar application focuses on the face shells of the blocks, the sides that face outward, and...
First Derivative Test: Problem Solving01:25

First Derivative Test: Problem Solving

Imagine an asset price that crashes to a low point, rebounds sharply as bargain-hunters step in, and then gradually declines. Such behavior can be modeled with a smooth function whose turning points represent locally overvalued and undervalued regions. A convenient example that captures rebound followed by decay is:The high and low points of this curve are identified using the first derivative test, which determines where the function changes from increasing to decreasing or vice versa. To...

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Updated: May 15, 2026

Determination of the Mechanical Properties of Flexible Connectors for Use in Insulated Concrete Wall Panels
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Determination of the Mechanical Properties of Flexible Connectors for Use in Insulated Concrete Wall Panels

Published on: October 19, 2022

Where the wall will fall first.

John Carroll

    Biotechnology Healthcare
    |January 16, 2013
    PubMed
    Summary
    This summary is machine-generated.

    Generic biologics are expected soon, with market entry timing depending on product complexity. Significant market disruption is anticipated as these therapies become available.

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    Area of Science:

    • Biopharmaceutical industry analysis
    • Market dynamics of therapeutic proteins

    Background:

    • The advent of generic biologics, also known as biosimilars, is a significant development in the pharmaceutical landscape.
    • The market exclusivity of originator biologic drugs is nearing expiration for many key therapies.

    Purpose of the Study:

    • To analyze the factors influencing the market entry timeline for generic biologics.
    • To identify which biologic therapies are most susceptible to market competition from biosimilars.

    Main Methods:

    • Review of patent expirations and regulatory pathways for biosimilar approval.
    • Analysis of product complexity and its impact on development timelines and interchangeability.

    Main Results:

    • The timeline for generic biologic market entry varies significantly based on the complexity of the reference product.
    • Certain high-value biologic markets are projected to face substantial competitive pressure in the near future.

    Conclusions:

    • The increasing availability of biosimilars will reshape the market for biologic therapies.
    • Strategic planning is crucial for stakeholders to navigate the evolving landscape of biologic drug competition.