Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Plant Breeding and Biotechnology

Plant Breeding and Biotechnology

Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.

Exercise and Cardiovascular Response

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...

The Central Dogma

The Central Dogma

The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...

Pathophysiology of Cardiac Performance

Pathophysiology of Cardiac Performance

Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...

Exercise and Cardiac Output

Exercise and Cardiac Output

Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be met...

What is Genetic Engineering?

What is Genetic Engineering?

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

For Autoimmune Ills, Biologics Bring Promise-And Problems.

Managed care (Langhorne, Pa.)·2017

Same author

Biosimilar Research Proceeds in Cancer, RA, and Hep B.

Managed care (Langhorne, Pa.)·2016

Same author

Biosimilars in Development Near End of Phase 3 Trials.

Managed care (Langhorne, Pa.)·2016

Same author

Digital Health Technology Adoption Depends On Tech Comfort Level, Willingness to Pay.

Managed care (Langhorne, Pa.)·2016

Same author

New Cancer Drugs Shine, but Costs May Dim Luster.

Managed care (Langhorne, Pa.)·2015

Same author

Sure, They're Cool, but Will Smart Wearables Ever Live Up to Their Potential?

Managed care (Langhorne, Pa.)·2015

Search research articles

Related Experiment Video

Updated: May 15, 2026

Slicing and Culturing Pig Hearts under Physiological Conditions

Slicing and Culturing Pig Hearts under Physiological Conditions

Published on: March 20, 2020

Will biotechnology keep the heart healthy?

Katherine T Adams

Biotechnology Healthcare

|January 16, 2013

Summary

This summary is machine-generated.

Coronary heart disease (CHD) remains a leading cause of death in America. Despite its prevalence, the development of novel CHD treatments by biotechnology companies has historically lagged, though advancements are anticipated.

More Related Videos

Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk

Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk

Published on: July 27, 2022

Cardiac Spheroids as in vitro Bioengineered Heart Tissues to Study Human Heart Pathophysiology

Cardiac Spheroids as in vitro Bioengineered Heart Tissues to Study Human Heart Pathophysiology

Published on: January 23, 2021

Related Experiment Videos

Last Updated: May 15, 2026

Slicing and Culturing Pig Hearts under Physiological Conditions

Slicing and Culturing Pig Hearts under Physiological Conditions

Published on: March 20, 2020

Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk

Viral Transgene Expression in Rodent Hearts and the Assessment of Cardiac Arrhythmia Risk

Published on: July 27, 2022

Cardiac Spheroids as in vitro Bioengineered Heart Tissues to Study Human Heart Pathophysiology

Cardiac Spheroids as in vitro Bioengineered Heart Tissues to Study Human Heart Pathophysiology

Published on: January 23, 2021

Area of Science:

Cardiovascular Medicine
Biotechnology
Pharmaceutical Research

Background:

Coronary heart disease (CHD) is the primary cause of mortality in the United States.
The development of effective treatments for CHD has not kept pace with its disease burden.
Understanding the reasons for this therapeutic lag is crucial for future progress.

Purpose of the Study:

To explore the reasons behind the slow progress in biotechnology-driven coronary heart disease treatment development.
To identify potential factors contributing to the historical underinvestment in this therapeutic area.
To forecast upcoming changes and innovations in CHD treatment research.

Main Methods:

Analysis of historical investment trends in cardiovascular drug development.
Review of scientific literature and patent filings related to CHD therapies.
Interviews with key opinion leaders in cardiology and biotechnology.

Main Results:

Identified significant barriers including complex disease pathology and high clinical trial costs.
Observed a historical trend of lower venture capital funding compared to other major diseases.
Noted emerging research in areas like genetic therapies and novel drug delivery systems.

Conclusions:

The development of new coronary heart disease treatments has been hindered by scientific and economic challenges.
Despite past lags, emerging biotechnologies and a renewed focus signal a coming shift in therapeutic innovation.
Future research and investment are expected to accelerate the creation of more effective CHD interventions.