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Updated: May 15, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

MET/HGF Signaling Pathway in Ovarian Carcinoma: Clinical Implications and Future Direction

Paulette Mhawech-Fauceglia1, Michelle Afkhami, Tanja Pejovic

  • 1Department of Pathology, University of Southern California, Room 7A116, 1200 N. State Street, Los Angeles, CA 90033-5000, USA.

Pathology Research International
|January 16, 2013
PubMed

Insights

The HGF/MET pathway drives ovarian cancer progression via invasive growth. Targeting this pathway offers a promising therapeutic strategy for ovarian cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Signaling

Background:

  • The Hepatocyte Growth Factor/MET (HGF/MET) signaling pathway is frequently dysregulated in various cancers.
  • MET is overexpressed in approximately 30% of ovarian cancer cases and cell lines, indicating its potential role in tumorigenesis.

Purpose of the Study:

  • To review the role of the HGF/MET pathway in ovarian cancer initiation and progression.
  • To discuss the clinical significance and therapeutic potential of targeting the HGF/MET axis in ovarian cancer.

Main Methods:

  • Literature review of studies investigating the HGF/MET pathway in ovarian cancer.
  • Analysis of the biological mechanisms underlying HGF/MET-driven "invasive growth" in ovarian cancer.
  • Examination of current clinical trials involving HGF/MET inhibitors.

Main Results:

  • The HGF/MET pathway promotes ovarian cancer through "invasive growth," involving cell motility, invasiveness, extracellular matrix degradation, survival, and proliferation.
  • MET overexpression is a common event in ovarian cancer, correlating with disease progression.

Conclusions:

  • The HGF/MET pathway is a critical driver of ovarian cancer.
  • Targeting the HGF/MET axis represents a significant therapeutic opportunity for future ovarian cancer treatments.

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