Related Experiment Video
Updated: May 15, 2026
Effects of Allogeneic Platelet-Rich Plasma (PRP) on the Healing Process of Sectioned Achilles Tendons of Rats: A Methodological Description
Published on: March 19, 2018
[Comparative study on animal model of acute Achilles tendon rupture with surgical treatment using platelet-rich
J C Hernández-Martínez1, C R Vásquez, C B Ceja
1Hospital General "Eduardo Vázquez Navarro" SSA Puebla, México. jcarlosmtez@hotmail.com
Objective:
To compare the functional and histologicalal course of two animal model groups with acute Achilles tendon tears using platelet rich plasma.
Material And Methods:
An open clinical trial was conducted with dogs donated by the animal facility of the Autonomous University of Puebla (BUAP, for its acronym in Spanish). Dogs were divided into 2 groups: a control group and a problem group. Intentional surgical Achilles tendon tear was performed to them. The Krackow technique was used to repair the tendon and the control group received platelet rich plasma (PRP) as a clot; the other group did not receive PRP. The dogs were seen at 4 weeks to check functionality using the Farell and Schwarz scale to assess the degree of limping. They were sacrificed at week 5; the tendons were removed and sent to the histopathology lab.
Results:
Functionality results according to the Farell and Schwarz scale showed grades I and II in the problem group, and grades IV and V in the control group. Histologically, the problem group showed moderate vascular proliferation and abundant fibroblastic proliferation. The control group had mild to moderate vascular proliferation and moderate fibroblastic proliferation.
Conclusions:
PRP improves tendon healing and this has repercussions on functional recovery.
