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Updated: May 15, 2026
07:55
Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
Chemotherapy use in elderly patients with soft tissue sarcoma: a population-based study.
Igor Matushansky1, Filemon Dela Cruz, Beverly J Insel
1Departments of Medicine, Columbia University, NY, USA.
Cancer Investigation
|January 17, 2013
Summary
Adjuvant chemotherapy for soft tissue sarcoma (STS) is controversial. This study found minimal chemotherapy use in resected and metastatic STS patients, with clinical factors influencing receipt in nonmetastatic cases.
Area of Science:
- Oncology
- Medical Informatics
Background:
- Adjuvant chemotherapy for soft tissue sarcoma (STS) lacks definitive survival benefits, particularly for metastatic disease.
- Chemotherapy use in STS is debated, necessitating analysis of real-world treatment patterns.
Purpose of the Study:
- To investigate the utilization and predictors of adjuvant chemotherapy in patients with resected and metastatic soft tissue sarcoma.
- To analyze chemotherapy receipt based on patient and tumor characteristics in a large population cohort.
Main Methods:
- Utilized the SEER-Medicare database to identify patients diagnosed with soft tissue sarcoma between 1991 and 2007.
- Analyzed data from 2,382 patients with resected STS and 365 patients with metastatic STS.
Main Results:
- Chemotherapy was administered to 4.5% of resected STS patients and 32.4% of metastatic STS patients.
- In resected STS, high tumor grade, larger size, and malignant fibrous histiocytoma subtype predicted chemotherapy receipt.
- In metastatic STS, younger age, fewer comorbidities, and being married were associated with chemotherapy receipt.
Conclusions:
- Chemotherapy utilization in soft tissue sarcoma is low, aligning with findings from clinical trials.
- Clinical factors significantly influence chemotherapy administration in nonmetastatic STS, highlighting potential areas for guideline refinement.
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