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Association of HLA-DRB1 single nucleotide polymorphisms with left ventricular remodelling in elderly patients with

Q M Li1, B Li, Y F Sun

  • 1First Hospital, Jilin University, Changchun, China.

The Journal of International Medical Research
|January 17, 2013
PubMed

Insights

Human leucocyte antigen DRβ1 (HLA-DRB1) gene variations, specifically rs2308765, are linked to left ventricular dilatation (LVD) in elderly hypertensive patients. This finding may help identify individuals at higher cardiovascular risk.

Area of Science:

  • Genetics
  • Cardiology
  • Immunology

Background:

  • Essential hypertension is a major risk factor for cardiovascular diseases.
  • Cardiovascular remodelling, such as left ventricular dilatation (LVD), is a common complication.
  • Human leucocyte antigen (HLA) genes play roles in immune responses and have been implicated in various diseases.

Purpose of the Study:

  • To investigate the association between HLA-DRB1 gene polymorphisms and LVD in elderly Han Chinese patients with essential hypertension.
  • To identify potential genetic markers for cardiovascular remodelling in this population.

Main Methods:

  • Echocardiography was used to diagnose LVD.
  • Genotyping of three HLA-DRB1 single nucleotide polymorphisms (SNPs): rs2308765, rs9269186, and rs3135388, was performed using multiplex polymerase chain reaction-ligase detection reaction.
  • Multivariate logistic regression analysis was employed to assess associations.

Main Results:

  • The wild-type (G) allele and (GG) genotype of HLA-DRB1 rs2308765 were associated with a decreased risk of LVD.
  • Conversely, the rs2308765 genotype (GT + TT) was significantly associated with an increased risk of LVD (OR 7.958, 95% CI 1.935-32.723).
  • No significant associations were found for HLA-DRB1 rs9269186 and rs3135388 with LVD risk. Larger waist and abdominal circumferences were observed in patients with LVD.

Conclusions:

  • Polymorphisms in the HLA-DRB1 rs2308765 gene are associated with an increased risk of LVD in elderly hypertensive patients.
  • HLA-DRB1 genotype analysis could aid in identifying patients at high risk for cardiovascular events like LVD.
Abstract

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