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Association between Sickle Cell Anemia and Pulp Necrosis
Cyrene Piazera Silva Costa1, Erika Bárbara Abreu Fonseca Thomaz, Soraia de Fátima Carvalho Souza
1Postgraduate Program in Dentistry, School of Dentistry, Federal University of Maranhão, São Luís, Maranhão, Brazil.
Journal of Endodontics
|January 17, 2013
Summary
Sickle cell anemia (SCA) significantly increases the risk of pulp necrosis (PN) in intact teeth. Individuals with SCA were over 8 times more likely to develop PN compared to those without the condition.
Area of Science:
- Dentistry
- Hematology
- Genetics
Background:
- Sickle cell anemia (SCA) is a genetic blood disorder.
- Pulp necrosis (PN) affects the vital tissue within teeth.
- The relationship between SCA and PN requires further investigation.
Purpose of the Study:
- To determine the association between sickle cell anemia (SCA) and pulp necrosis (PN).
Main Methods:
- A case-control study involving 113 individuals with SCA and 226 controls.
- Participants were over 16 years old with intact permanent teeth.
- Pulp necrosis diagnosed via cold thermal test and pulse oximetry; Poisson regression used for analysis.
Main Results:
- Pulp necrosis was 8.33 times more frequent in individuals with SCA.
- The association remained statistically significant after adjusting for orofacial trauma and folic acid use.
Conclusions:
- Sickle cell anemia is identified as a potential risk factor for pulp necrosis in clinically intact teeth.
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