Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Layers of the Epidermis01:21

Layers of the Epidermis

The epidermis, the outermost layer of the skin, is composed of several distinct layers. From deep to superficial, the layers of the epidermis are as follows:
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Introduction to the Integumentary System01:25

Introduction to the Integumentary System

The integumentary system is the organ system that comprises the skin and its associated structures. It is the largest system in the human body and plays a crucial role in protecting and maintaining homeostasis. The integumentary system serves several functions including protection, regulation, sensation, and secretion.
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Itch Relief and Quality-of-Life Improvement with Abrocitinib and Dupilumab in Patients with Moderate-to-Severe Atopic Dermatitis: A Post Hoc Analysis of JADE COMPARE and JADE DARE.

American journal of clinical dermatology·2026
Same author

Corticosteroid-Associated Adverse Events in Chronic Spontaneous Urticaria: A US Claims Data Study.

Dermatology and therapy·2026
Same author

Association of morbid obesity with atopic dermatitis differs by race and sex in a dermatology clinic cohort.

Journal of the American Academy of Dermatology·2026
Same author

Sphenopalatine Ganglion Radiofrequency Ablation for Severe Facial Rosacea Manifestations.

Pain practice : the official journal of World Institute of Pain·2026
Same author

Correction: Dupilumab Reduces Pruritus in Clinically Distinct Dermatologic Diseases: Data from Clinical Trials on Atopic Dermatitis, Prurigo Nodularis, and Chronic Spontaneous Urticaria.

Dermatology and therapy·2026
Same author

Efficacy of Remibrutinib versus Dupilumab at Early Timepoints in Chronic Spontaneous Urticaria: US Phase 3b Study Design (RECLAIM).

Dermatology and therapy·2026
Same journal

A Facial Lesion with Cord-like Induration and Ring-like Appearance on MRI: A Quiz.

Acta dermato-venereologica·2026
Same journal

Real-world Outcomes of Adalimumab in Hidradenitis Suppurativa: A 10-year Retrospective Longitudinal Study.

Acta dermato-venereologica·2026
Same journal

An 8-year-old Girl with Multiple Whitish Dots on the Hair Shaft: A Quiz.

Acta dermato-venereologica·2026
Same journal

A Congenital Subcutaneous Tumour of the Scalp in a Child: A Quiz.

Acta dermato-venereologica·2026
Same journal

Commentary on: "The Effects of Sun Exposure and Pigmentation Phenotype on Prognosis in Metastatic Melanoma".

Acta dermato-venereologica·2026
Same journal

Treatment Response to JAK Inhibitors in Long-standing Alopecia Areata (≥8 Years): A Real-world Observational Study.

Acta dermato-venereologica·2026
See all related articles

Related Experiment Video

Updated: May 15, 2026

Building Up Skin Models for Numerous Applications - from Two-Dimensional (2D) Monoculture to Three-Dimensional (3D) Multiculture
08:32

Building Up Skin Models for Numerous Applications - from Two-Dimensional (2D) Monoculture to Three-Dimensional (3D) Multiculture

Published on: October 20, 2023

Skin pH: from basic science to basic skin care.

Saba M Ali1, Gil Yosipovitch

  • 1Department of Dermatology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

Acta Dermato-Venereologica
|January 17, 2013
PubMed
Summary
This summary is machine-generated.

The skin's acid mantle, crucial for barrier function, is vital for skin health but often overlooked in clinical practice. Understanding and preserving skin pH is key to treating dermatologic conditions.

More Related Videos

Generation and Culturing of Primary Human Keratinocytes from Adult Skin
10:42

Generation and Culturing of Primary Human Keratinocytes from Adult Skin

Published on: December 22, 2017

Preparation of Keratin Hydrolysate from Chicken Feathers and Its Application in Cosmetics
08:29

Preparation of Keratin Hydrolysate from Chicken Feathers and Its Application in Cosmetics

Published on: November 27, 2017

Related Experiment Videos

Last Updated: May 15, 2026

Building Up Skin Models for Numerous Applications - from Two-Dimensional (2D) Monoculture to Three-Dimensional (3D) Multiculture
08:32

Building Up Skin Models for Numerous Applications - from Two-Dimensional (2D) Monoculture to Three-Dimensional (3D) Multiculture

Published on: October 20, 2023

Generation and Culturing of Primary Human Keratinocytes from Adult Skin
10:42

Generation and Culturing of Primary Human Keratinocytes from Adult Skin

Published on: December 22, 2017

Preparation of Keratin Hydrolysate from Chicken Feathers and Its Application in Cosmetics
08:29

Preparation of Keratin Hydrolysate from Chicken Feathers and Its Application in Cosmetics

Published on: November 27, 2017

Area of Science:

  • Dermatology
  • Skin Physiology
  • Biochemistry

Background:

  • The acid mantle, a protective film on the skin surface, plays a critical role in maintaining skin barrier homeostasis.
  • Despite established scientific evidence linking skin pH to barrier integrity and antimicrobial defense, its clinical application remains limited.
  • The stratum corneum's function is intrinsically tied to the maintenance of the skin's acidic pH.

Purpose of the Study:

  • To review recent scientific investigations into skin pH.
  • To discuss skin disorders associated with abnormal skin pH.
  • To explore practical strategies for preserving the acid mantle in clinical settings.

Main Methods:

  • Literature review of basic science research on skin pH.
  • Analysis of clinical data on skin disorders with aberrant pH.
  • Discussion of product formulation and patient care strategies.

Main Results:

  • Skin pH is a fundamental factor in epidermal barrier function, stratum corneum integrity, and the skin's natural antimicrobial defense.
  • Several skin disorders are characterized by significant deviations in skin pH.
  • Factors influencing skin pH are identifiable, and product selection can impact mantle preservation.

Conclusions:

  • Preserving the acid mantle is paramount in managing dermatologic conditions.
  • Recognizing factors that disrupt skin pH is essential for effective patient treatment.
  • Clinical application of the acid mantle concept requires greater emphasis in dermatological care.