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Related Experiment Video

Updated: May 15, 2026

Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration
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The neonatal autopsy: can it be revived?

Cameron H Swinton1, Julie Weiner, Felix A Okah

  • 1Section of Neonatal-Perinatal Medicine, Children's Mercy Hospitals and Clinics, Kansas City, Missouri.

American Journal of Perinatology
|January 17, 2013
PubMed
Summary

Autopsy rates in neonatal intensive care units (NICUs) are declining, even when offered to all parents. Factors like gestational age and absence of congenital anomalies influence autopsy likelihood, highlighting the need to emphasize their value.

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Area of Science:

  • Neonatalogy
  • Pathology
  • Medical Ethics

Background:

  • Autopsies are crucial for determining cause of death and improving future care.
  • Declining autopsy rates in neonatal intensive care units (NICUs) are a growing concern.
  • Understanding factors influencing autopsy decisions is vital for medical practice.

Purpose of the Study:

  • To analyze trends in autopsy rates over a decade in a level III NICU.
  • To identify demographic and clinical factors associated with autopsy decisions.
  • To evaluate the impact of offering autopsies to all parents.

Main Methods:

  • Retrospective cohort study of infant deaths in a NICU from 2001-2010.
  • Analysis of 446 deaths, examining autopsy rates and associated variables.

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  • Multivariable logistic regression to identify predictors of autopsy.

    • Main Results:

    • Autopsy rates were 33.9% and showed a decreasing trend.
    • Autopsy likelihood increased with gestational age at birth.
    • Autopsies were more common in infants who died post-neonatally and lacked major congenital anomalies.

    Conclusions:

    • Autopsy rates continue to decline despite universal offering.
    • Infants born at term and those without congenital anomalies are more likely to undergo autopsy.
    • Low rates underscore the need to educate families on autopsy utility, even in seemingly obvious cases.