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Related Concept Videos

Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized by phagocytes.
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...

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Corrigendum to "Adrenocortical carcinomas and malignant phaeochromocytomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up": [Annals of Oncology volume 31 (2020) 1476-1490].

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Related Experiment Video

Updated: May 15, 2026

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

Mortality associated with phaeochromocytoma.

A Prejbisz1, J W M Lenders, G Eisenhofer

  • 1Department of Hypertension, Institute of Cardiology, Warsaw, Poland. aprejbisz@ikard.pl

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|January 17, 2013
PubMed
Summary

Phaeochromocytoma can cause death from excess catecholamines or metastatic disease. Early diagnosis and treatment, especially during pregnancy, significantly reduce mortality rates from this rare adrenal tumor.

Related Experiment Videos

Last Updated: May 15, 2026

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

Area of Science:

  • Endocrinology
  • Oncology
  • Cardiovascular Medicine

Background:

  • Phaeochromocytoma, a rare adrenal tumor, presents significant mortality risks.
  • Mortality stems from excessive catecholamine effects or metastatic/neoplastic complications.
  • Historically, undiagnosed tumors led to severe, often fatal, cardiovascular events.

Purpose of the Study:

  • To delineate the primary causes of mortality in phaeochromocytoma patients.
  • To assess the impact of diagnostic and therapeutic advancements on patient outcomes.
  • To review mortality risks associated with malignant phaeochromocytoma and pregnancy.

Main Methods:

  • Review of existing literature on phaeochromocytoma mortality.
  • Analysis of causes of death, including catecholamine excess, metastasis, and iatrogenic factors.
  • Comparison of historical and contemporary mortality rates, particularly in surgical and pregnant patients.

Main Results:

  • Mortality is categorized into acute catecholamine effects and long-term neoplastic progression.
  • Improved diagnosis has reduced deaths from undiagnosed tumors, but cardiovascular complications remain a risk.
  • Surgical mortality is now minimal in medically prepared patients; malignant disease and secondary tumors increase risk.
  • Maternal mortality in pregnancy-associated phaeochromocytoma has decreased to <5% due to earlier recognition and management.

Conclusions:

  • While advancements have improved survival, phaeochromocytoma remains a condition with significant mortality potential.
  • Vigilance for cardiovascular complications, metastatic disease, and secondary neoplasms is crucial.
  • Effective management strategies have dramatically improved outcomes, especially for pregnant patients.