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Updated: May 15, 2026

Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
A centralized research data repository enhances retrospective outcomes research capacity: a case report
Gregory William Hruby1, James McKiernan, Suzanne Bakken
1Department of Urology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. ghr7001@dbmi.columbia.edu
Abstract:
This paper describes our considerations and methods for implementing an open-source centralized research data repository (CRDR) and reports its impact on retrospective outcomes research capacity in the urology department at Columbia University. We performed retrospective pretest and post-test analyses of user acceptance, workflow efficiency, and publication quantity and quality (measured by journal impact factor) before and after the implementation. The CRDR transformed the research workflow and enabled a new research model. During the pre- and post-test periods, the department's average annual retrospective study publication rate was 11.5 and 25.6, respectively; the average publication impact score was 1.7 and 3.1, respectively. The new model was adopted by 62.5% (5/8) of the clinical scientists within the department. Additionally, four basic science researchers outside the department took advantage of the implemented model. The average proximate time required to complete a retrospective study decreased from 12 months before the implementation to <6 months after the implementation. Implementing a CRDR appears to be effective in enhancing the outcomes research capacity for one academic department.
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