Related Experiment Video

Updated: May 15, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

[Molecular targeted cancer therapy and genetic tests --chairman's introductory remarks]

Yuji Hinoda1

  • 1Yamaguchi University Graduate School of Medicine, Department of Oncology and Laboratory Medicine, Ube 755-8505, Japan. hinoda@yamaguchi-u.ac.jp

Rinsho Byori. the Japanese Journal of Clinical Pathology
|January 18, 2013
PubMed

Insights

Genetic tests are advancing cancer therapy through pharmacogenomics and targeted treatments. This symposium highlights recent breakthroughs in genetic testing for breast, lung, colorectal, and blood cancers.

Area of Science:

  • Oncology
  • Pharmacogenomics
  • Molecular Biology

Context:

  • Genetic testing was limited to rare and hematopoietic tumors in the 1990s.
  • Molecular targeted therapy has expanded to common solid tumors in the 21st century.
  • Advances in molecular targeted therapy drive the evolution of genetic tests.

Purpose:

  • To present recent advances in genetic tests for molecular targeted therapy.
  • To showcase applications in common solid tumors and hematopoietic malignancies.

Summary:

  • The repertoire of genetic tests for individualized cancer therapy is expanding.
  • Pharmacogenomics biomarkers and molecular targeted therapies are key drivers of this progress.
  • Recent symposium presentations cover breast, lung, colorectal, and hematopoietic cancers.

Impact:

  • Breakthroughs in genetic testing are enabling more precise cancer treatments.
  • The application of molecular targeted therapy has broadened significantly.
  • Individualized cancer therapy is becoming more accessible for a wider range of patients.

More Related Videos

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

Targeted RNA Sequencing Assay to Characterize Gene Expression and Genomic Alterations11:52

Targeted RNA Sequencing Assay to Characterize Gene Expression and Genomic Alterations

Published on: August 4, 2016

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...