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Updated: May 15, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
[Calcium pyrophosphate dihydrate crystal deposition disease: a clinicopathologic analysis of 20 cases]
Hui-qiong Fang1, Qi-ming Li, Yao-qu Huang
1Department of Pathology, Foshan Hospital of Traditional Chinese Medicine, Foshan 528000, China. fhq039@yahoo.com.cn
Objective:
To investigate the clinicopathologic features of calcium pyrophosphate dihydrate crystal deposition disease (CPPD-CDD).
Methods:
The clinical and pathologic profiles were retrospectively analysed in 20 cases of CPPD-CDD.
Results:
CPPD-CDD was far more common in women, most frequently involving joints, especially the knees and presenting with various arthrisis. Abnormally calcified and the articular damages were characteristic features by imageing. Histologically, multifocal indigo granular calcinosis was seen in synovium and sometimes appeared as needle-shaped or rhomboid crystals, which characterized the CPPD.
Conclusions:
Though clinical symptoms of CPPD are quite variable, the definite diagnosis can be made by the abnormal calcification and joint damage radiographically and the indigo CPPD crystals histopathologically.
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