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A High-throughput Platform for the Screening of Salmonella spp./Shigella spp.
Published on: November 7, 2018
Using next generation sequencing to tackle non-typhoidal Salmonella infections
John Wain1, Karen H Keddy, Rene S Hendriksen
1Norwich Medical School, University of East Anglia, Norwich, UK. j.wain@uea.ac.uk
Journal of Infection in Developing Countries
|January 18, 2013
Summary
Multidrug-resistant Salmonella Typhimurium ST313 is emerging in Africa, primarily spreading human-to-human and causing invasive disease. Further research is needed to rule out animal reservoirs and enhance frontline laboratory surveillance for all Salmonella infections.
Area of Science:
- Microbiology
- Epidemiology
- Public Health
- Genomics
Background:
- Next-generation sequencing (NGS) is revolutionizing the analysis of bacterial isolates from global epidemics.
- Multidrug-resistant (MDR) Salmonella Typhimurium ST313 is a significant public health concern, particularly in sub-Saharan Africa.
- Understanding the epidemiology and transmission dynamics of MDR Salmonella is crucial for effective public health interventions.
Purpose of the Study:
- To review current knowledge on non-typhoidal Salmonella in sub-Saharan Africa.
- To discuss the epidemiology and transmission of Salmonella Typhimurium ST313.
- To identify remaining challenges in Salmonella surveillance and control.
Main Methods:
- Literature review of studies on Salmonella in sub-Saharan Africa.
- Analysis of data on Salmonella Typhimurium ST313 emergence and spread.
- Discussion of genomic and epidemiological findings.
Main Results:
- Salmonella Typhimurium ST313 exhibits predominantly human-to-human transmission in Africa.
- Invasive disease is strongly associated with this MDR strain.
- The potential role of animal reservoirs requires further investigation.
Conclusions:
- NGS has transformed our understanding of bacterial pathogens like Salmonella.
- Continued research is essential to elucidate potential animal reservoirs and improve frontline laboratory capacity for Salmonella surveillance in sub-Saharan Africa.
- Effective control strategies require a comprehensive understanding of transmission dynamics.
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