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Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Related Experiment Video

Updated: May 15, 2026

Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane

Functional Characterization of Na⁺/H⁺ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane

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Genetic association between RGS1 and internalizing disorders.

John M Hettema¹, Seon-Sook An, Edwin J C G van den Oord

¹Departments of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA 23298-0126, USA.

Psychiatric Genetics

|January 18, 2013

Summary

This summary is machine-generated.

Genetic markers in the regulator of G-protein signaling 1 (RGS1) gene may reduce the risk for internalizing disorders like anxiety and depression. This finding links rodent emotionality loci to human chromosome 1.

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Area of Science:

Genetics
Psychiatric Disorders
Neuroscience

Background:

Quantitative trait loci (QTLs) in animal models can indicate potential human disorder susceptibility loci.
Internalizing disorders, including anxiety, depression, and neuroticism, represent significant public health concerns.
Previous research suggests a link between rodent emotionality QTLs and human chromosome regions.

Purpose of the Study:

To investigate the association between human chromosome 1q31.2 and internalizing disorders.
To determine if a region syntenic to a rodent emotionality QTL influences susceptibility to human internalizing disorders.

Main Methods:

A two-stage association study was conducted on 1128 individuals from the Virginia Adult Twin Study.
Genotyping of 31 single-nucleotide polymorphisms (SNPs) in genes located on chromosome 1q31.2 was performed.
Participants were selected based on high or low genetic risk for internalizing disorders.

Main Results:

No individual SNPs showed consistent association with internalizing disorders across both study stages.
A four-marker haplotype in the regulator of G-protein signaling 1 (RGS1) gene was significantly associated with reduced internalizing risk.
Another RGS1 haplotype showed a nominal association with increased internalizing risk.

Conclusions:

The findings suggest that specific markers within the RGS1 gene may be in linkage disequilibrium with a protective allele.
This protective allele appears to reduce the risk for developing anxiety and depressive disorders.
The study highlights the potential role of RGS1 in the genetic architecture of internalizing disorders.