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Updated: May 15, 2026

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
[Assessment of diastolic heart failure. Current role of echocardiography]
F Weidemann1, M Niemann, S Herrmann
1Comprehensive Heart Failure Center Würzburg, Medizinische Klinik und Poliklinik I, Universitätsklinik Würzburg, Oberdürrbacherstrasse 6, Würzburg, Germany. weidemann_f@medizin.uni-wuerzburg.de
Insights
Diastolic heart failure (HF-pEF) affects half of all heart failure cases. This review details echocardiography techniques for diagnosing diastolic dysfunction, a key HF-pEF criterion.
Area of Science:
- Cardiology
- Medical Imaging
Background:
- Diastolic heart failure, or heart failure with preserved left ventricular ejection fraction (HF-pEF), accounts for 50% of heart failure cases.
- Diagnosis requires symptoms, normal ejection fraction, and diastolic dysfunction evidence.
Purpose of the Study:
- To provide a comprehensive overview of echocardiographic techniques for assessing diastolic function.
- To present an algorithm for routine diastolic dysfunction evaluation.
Main Methods:
- Review of established and novel echocardiography parameters for diastolic function assessment.
- Discussion of parameters including atrial dimensions, mitral inflow, pulmonary vein flow, and tissue Doppler.
- Utilization of maneuvers like Valsalva and consideration of conditions like atrial fibrillation.
Main Results:
- Echocardiography is the primary diagnostic tool for HF-pEF, especially after excluding other dyspnea causes.
- Diastolic dysfunction often correlates with increased atrial size and left ventricular hypertrophy.
- Specific echocardiographic parameters like E/A ratio, deceleration time, and E/e' are crucial for grading diastolic function.
Conclusions:
- Echocardiography offers a robust method for evaluating diastolic function in HF-pEF.
- Established and newer techniques are vital for accurate diagnosis and management.
- A structured approach using an algorithm aids in routine assessment of diastolic dysfunction.
Abstract:
Diastolic heart failure, also known as heart failure with preserved left ventricular ejection fraction (HF-pEF), is responsible for approximately 50 % of all heart failure cases. According to current guidelines the diagnosis HF-pEF requires three criteria: (1) signs or symptoms of heart failure, (2) presence of a normal left ventricular ejection fraction and (3) evidence of diastolic dysfunction. Echocardiography is the diagnostic modality of choice, especially after ruling out other causes of dyspnea, such as pulmonary diseases, heart rhythm disturbances and volume overload. Important echocardiographic parameters for the assessment of diastolic function are atrial dimensions, myocardial mass, mitral inflow pattern, pulmonary vein flow, propagation velocity of mitral inflow and the tissue Doppler of the mitral annulus. Nevertheless, a complete echocardiographic examination should be performed in every patient with heart failure. In general, diastolic dysfunction is frequently associated with increased atrial diameter and left ventricular hypertrophy. In advanced stages pulmonary hypertension can be present. A robust method for evaluation of systolic function in patients with diastolic dysfunction is crucial. The mitral inflow pattern provides various parameters to describe diastolic function (E/A ratio, deceleration time, isovolumetric relaxation time). In case of difficulties to separate a normal from a pseudonormal mitral inflow pattern the Valsalva maneuver can be used. Another valuable parameter for this differentiation is the duration of the backward flow in the pulmonary veins in contrast to forward flow over the mitral valve. Tachycardia or atrial fibrillation is a major problem for grading of diastolic function; however, in patients with atrial fibrillation E/e' is a well-established parameter. In summary, this review provides a detailed overview and discussion of the established and newer echocardiography techniques for the evaluation of diastolic function and provides an algorithm for the assessment of diastolic dysfunction in everyday routine.
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