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Updated: May 15, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis of bisindolylmethanes and their cytotoxicity properties
Kalla Reddi Mohan Naidu1, Shaik Ibrahim Khalivulla, Syed Rasheed
1Department of Food Technology, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia. lasekan@food.upm.edu.my.
Abstract:
Polymer supported dichlorophosphate (PEG-OPOCl(2)) is an efficient green catalyst for the electrophilic substitution reaction of indole with aromatic aldehydes, in neat condition, to afford an excellent yield of bis(indolyl) methanes with short reaction time, at room temperature. The synthesized compounds and their anti-cancer activity are evaluated.
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