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Related Experiment Video

Updated: May 15, 2026

Multi-electrode Array Recordings of Neuronal Avalanches in Organotypic Cultures

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Published on: August 1, 2011

Layer III neurons control synchronized waves in the immature cerebral cortex.

Shigehiro Namiki¹, Hiroaki Norimoto, Chiaki Kobayashi

¹Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|January 18, 2013

Summary

Correlated spiking activity in immature rat brains forms traveling waves originating in the entorhinal cortex. These waves, driven by glutamatergic receptors, highlight the crucial role of layer III neurons in early cortical development.

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Published on: November 21, 2023

Area of Science:

Neuroscience
Developmental Neuroscience
Computational Neuroscience

Background:

Immature cortical networks exhibit correlated spiking activity, crucial for neuronal circuit maturation.
The precise spatiotemporal organization of this early activity remains incompletely understood.

Purpose of the Study:

To investigate the spatiotemporal dynamics of correlated spiking activity in the developing rat cortex.
To elucidate the circuit mechanisms underlying early cortical network organization and maturation.

Main Methods:

Wide-field calcium imaging in acute whole-brain slices from postnatal day 1-6 rat pups.
Pharmacological manipulation using ionotropic glutamatergic and GABAergic receptor antagonists.
Cellular resolution monitoring to identify neuronal activation patterns.

Main Results:

Correlated spikes propagated as traveling waves across the cortex, initiated in the anterior lateral entorhinal cortex.
Waves were dependent on ionotropic glutamatergic receptors and involved balanced synaptic inputs, inducing UP state-like depolarization.
Layer III neurons were preferentially activated at wave initiation and formed the leading front during propagation.
Waves were blocked from entering the parasubiculum but could reflect, with layer III neurons showing persistent activity during reflection.

Conclusions:

Layer III neurons play a critical role in initiating and guiding early cortical network activity.
Traveling waves represent a fundamental mechanism for cortical circuit maturation in early development.
The findings provide insights into the circuit basis of early network behaviors and cerebral cortical development.