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Related Experiment Videos

Multiple organ failure--a role for plasma exchange?

P McClelland1, P S Williams, M Yaqoob

  • 1Department of Renal Medicine, Royal Liverpool Hospital, UK.

Intensive Care Medicine
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

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Plasma exchange (PE) shows promise for severe sepsis. This adjunctive therapy improved cardio-respiratory, neurological, and renal functions in two patients with multiple organ failure and overwhelming sepsis.

Area of Science:

  • Critical Care Medicine
  • Nephrology
  • Infectious Diseases

Background:

  • Sepsis with multiple organ failure presents a severe clinical challenge.
  • Standard supportive measures are often insufficient for deteriorating patients.

Observation:

  • Two patients with overwhelming sepsis and multiple organ failure were treated with plasma exchange.
  • Both patients exhibited a declining clinical course prior to intervention.

Findings:

  • Plasma exchange led to significant improvements in cardio-respiratory function in patient 1.
  • Patient 2 demonstrated notable recovery in neurological and renal parameters post-plasma exchange.
  • These clinical improvements were directly attributed to the plasma exchange therapy.

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Implications:

  • Plasma exchange may serve as a valuable adjunctive treatment for severe sepsis.
  • This approach could be beneficial in cases of overwhelming sepsis complicated by multiple organ failure.
  • Further research is warranted to confirm the efficacy and safety of plasma exchange in sepsis management.