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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
Microbial Corrosion01:24

Microbial Corrosion

Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Related Experiment Video

Updated: May 15, 2026

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment
06:48

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

Published on: April 29, 2022

MicroRNAs in metabolic disease.

Carlos Fernández-Hernando1, Cristina M Ramírez, Leigh Goedeke

  • 1Departments of Medicine and Cell Biology, Leon H. Charney Division of Cardiology and the Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, NY, USA. carlos.fernandez-hernando@nyumc.org

Arteriosclerosis, Thrombosis, and Vascular Biology
|January 18, 2013
PubMed
Summary

MicroRNAs (miRNAs) are key regulators of lipid and glucose metabolism. Targeting specific miRNAs offers a promising therapeutic strategy for cardiometabolic diseases like type 2 diabetes and atherosclerosis.

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In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

Related Experiment Videos

Last Updated: May 15, 2026

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment
06:48

Quantitative Real-Time Polymerase Chain Reaction Evaluation of MicroRNA Expression in Kidney and Serum of Mice with Age-Dependent Renal Impairment

Published on: April 29, 2022

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Metabolic dysregulation of lipid and glucose homeostasis contributes to cardiometabolic diseases.
  • MicroRNAs (miRNAs) have emerged as critical regulators of metabolic processes.
  • Specific miRNAs, like miR-33 and miR-122, influence key metabolic pathways.

Purpose of the Study:

  • To review recent findings on the role of miRNAs in regulating lipid and glucose metabolism.
  • To highlight the contribution of specific miRNAs, such as miR-33 and miR-122, in metabolic control.
  • To discuss the therapeutic potential of miRNA modulation for metabolic diseases.

Main Methods:

  • Literature review of recent research findings.
  • Analysis of the regulatory roles of specific miRNAs (e.g., miR-33, miR-122) in metabolic pathways.
  • Discussion of experimental evidence supporting miRNA involvement in homeostasis.

Main Results:

  • miRNAs significantly impact lipid and glucose homeostasis.
  • miR-33 regulates cholesterol export, fatty acid degradation, and synthesis.
  • miR-122 is crucial for hepatic cholesterol synthesis and lipoprotein secretion.

Conclusions:

  • miRNAs are vital in maintaining metabolic balance.
  • Dysregulation of miRNAs contributes to cardiometabolic disease development.
  • Modulating specific miRNAs presents a potential therapeutic avenue for metabolic disorders.