Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trimethylamine N-oxide and related metabolites may regulate DNA methylation and trigger cardiovascular disease.

Clinical epigenetics·2026
Same author

Epigenetic mediators of diet and lifestyle and insulin resistance.

Genes & nutrition·2026
Same author

Sweet Taste Genetic Risk Score and Alignment to Diet Quality among Puerto Rican Adults in Massachusetts.

The Journal of nutrition·2026
Same author

Metabolite Genome-Wide Association in Hispanics with Obesity Reveals Genetic Risk and Interactions with Dietary Factors for Type 2 Diabetes.

Metabolites·2025
Same author

Exploration of Biomarkers of Food Intake in a Caribbean Hispanic Population.

Molecular nutrition & food research·2025
Same author

Differential weight-loss responses of APOA2 genotype carriers to low-carbohydrate and low-fat diets: the DIETFITS trial.

Obesity (Silver Spring, Md.)·2025
Same journal

Targeting the Tumor Immune Ecosystem in Glioblastoma: Challenges and Innovations in Immunotherapy.

BioFactors (Oxford, England)·2026
Same journal

Platelet-Related Gene Signature Predicts Prognosis, Immune Landscape, and Drug Sensitivity in Acute Myeloid Leukemia.

BioFactors (Oxford, England)·2026
Same journal

Resveratrol-Derived Dimers With Antimicrobial and Immune-Enhancing Activities.

BioFactors (Oxford, England)·2026
Same journal

Lysine Lactylation: Dynamic Regulation in the Tumor Microenvironment and Clinical Translational Prospects.

BioFactors (Oxford, England)·2026
Same journal

Lipid Codes and Lipid-Binding Proteins as Central Regulators of Autophagy.

BioFactors (Oxford, England)·2026
Same journal

Mesenchymal Stem Cell-Derived Exosomal miR-29a-3p Improves Hypertrophic Scar by Inhibiting the Proliferation and Migration of Schwann Cells via the PDGFRB/PAK1 Axis.

BioFactors (Oxford, England)·2026
See all related articles

Related Experiment Video

Updated: May 15, 2026

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells
12:55

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

Published on: October 10, 2017

Curcumin and aging.

Li-Rong Shen1, Laurence D Parnell, Jose M Ordovas

  • 1Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.

Biofactors (Oxford, England)
|January 18, 2013
PubMed
Summary
This summary is machine-generated.

Curcumin, a turmeric extract, extends lifespan in worms, flies, and mice by reducing oxidative stress and regulating age-related genes. This natural compound shows promise for interventions against aging and related diseases.

More Related Videos

Labeling and Imaging of Amyloid Plaques in Brain Tissue Using the Natural Polyphenol Curcumin
10:15

Labeling and Imaging of Amyloid Plaques in Brain Tissue Using the Natural Polyphenol Curcumin

Published on: November 1, 2019

Enhanced Photoluminescence of Curcuma longa Extracts via Chitosan-Mediated Energy Transfer for Textile Authentication Applications
09:50

Enhanced Photoluminescence of Curcuma longa Extracts via Chitosan-Mediated Energy Transfer for Textile Authentication Applications

Published on: December 22, 2023

Related Experiment Videos

Last Updated: May 15, 2026

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells
12:55

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

Published on: October 10, 2017

Labeling and Imaging of Amyloid Plaques in Brain Tissue Using the Natural Polyphenol Curcumin
10:15

Labeling and Imaging of Amyloid Plaques in Brain Tissue Using the Natural Polyphenol Curcumin

Published on: November 1, 2019

Enhanced Photoluminescence of Curcuma longa Extracts via Chitosan-Mediated Energy Transfer for Textile Authentication Applications
09:50

Enhanced Photoluminescence of Curcuma longa Extracts via Chitosan-Mediated Energy Transfer for Textile Authentication Applications

Published on: December 22, 2023

Area of Science:

  • Biochemistry
  • Gerontology
  • Molecular Biology

Background:

  • Turmeric extract, curcumin, is a bioactive polyphenol with diverse health benefits.
  • Curcumin and its metabolite tetrahydrocurcumin (THC) have shown lifespan-extending properties in model organisms.

Purpose of the Study:

  • To investigate the effects of curcumin and THC on lifespan and aging-related mechanisms in model organisms.
  • To elucidate the molecular pathways through which curcumin influences aging.

Main Methods:

  • Lifespan assays were conducted on nematode roundworms, fruit flies (Drosophila), and mice supplemented with curcumin or THC.
  • Gene expression analysis and biochemical assays (e.g., reactive oxygen species, SOD activity, lipofuscin, malondialdehyde) were performed.

Main Results:

  • Curcumin significantly increased mean lifespan in nematodes, fruit flies, and mice.
  • Lifespan extension was linked to reduced reactive oxygen species, increased superoxide dismutase activity, and modulation of specific age-related genes.
  • Tetrahydrocurcumin also extended lifespan in fruit flies and mice, inhibiting oxidative stress responses.

Conclusions:

  • Curcumin and THC promote lifespan extension across multiple model organisms.
  • The beneficial effects are mediated by the regulation of oxidative stress pathways and age-related genes.
  • Findings support further research into curcumin for human clinical trials and nutritional interventions for aging.