Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Exercise and Muscle Performance01:27

Exercise and Muscle Performance

Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Cellular Adaptation II: Hypertrophy01:26

Cellular Adaptation II: Hypertrophy

Hypertrophy is the increase in the size of individual cells, resulting in the enlargement of a tissue or organ. Unlike hyperplasia, which involves an increase in cell number, hypertrophy is characterized by an increase in cell volume. This process often occurs in response to higher functional demand or hormonal stimulation, leading to the production of more structural proteins and organelles, thereby enhancing the cells' work capacity.There are two primary types of hypertrophy: physiological...
Exercise and Cardiac Output01:17

Exercise and Cardiac Output

Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be met...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resting-state functional connectivity and cognitive impairment after COVID-19 infection: Evidence from a large-scale fMRI study.

European psychiatry : the journal of the Association of European Psychiatrists·2026
Same author

ATP1A3-related syndromes: our case-series unveiling a dynamic, fever-triggered and overlapping array of neurological phenotypes.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

The hypoxia-inflammation cycle as a key mechanism of smoldering inflammation and progression in multiple sclerosis.

Acta neuropathologica·2026
Same author

Management strategies, complication rate and outcome following treatment of para-aural abscessation as a complication of total ear canal ablation and lateral bulla osteotomy surgery.

Australian veterinary journal·2026
Same author

Lipegfilgrastim for primary prophylaxis of febrile neutropenia in patients treated for advanced-stage classical hodgkin lymphoma: successful outcomes from a multicenter cohort study.

Annals of hematology·2026
Same author

Intraoperative use of N-butyl cyanoacrylate for the management of pneumothorax secondary to small air leaks in pulmonary surgery.

The Journal of small animal practice·2025

Related Experiment Video

Updated: May 15, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Moderate exercise training induces ROS-related adaptations to skeletal muscles.

P M Abruzzo1, F Esposito, C Marchionni

  • 1Department of Histology, Embryology, and Applied Biology, University of Bologna, Bologna, Italy.

International Journal of Sports Medicine
|January 18, 2013
PubMed
Summary

Moderate exercise training induced muscle adaptations in rat Tibialis Anterior (TA) and Soleus (SOL) muscles. Exercise increased muscle regulatory factors, leading to hypertrophy in SOL and hyperplasia in TA, with muscle-specific metabolic and oxidative stress responses.

More Related Videos

Application of Chronic Stimulation to Study Contractile Activity-induced Rat Skeletal Muscle Phenotypic Adaptations
09:50

Application of Chronic Stimulation to Study Contractile Activity-induced Rat Skeletal Muscle Phenotypic Adaptations

Published on: January 25, 2018

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique
07:20

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique

Published on: September 10, 2014

Related Experiment Videos

Last Updated: May 15, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Application of Chronic Stimulation to Study Contractile Activity-induced Rat Skeletal Muscle Phenotypic Adaptations
09:50

Application of Chronic Stimulation to Study Contractile Activity-induced Rat Skeletal Muscle Phenotypic Adaptations

Published on: January 25, 2018

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique
07:20

Human Skeletal Muscle Biopsy Procedures Using the Modified Bergström Technique

Published on: September 10, 2014

Area of Science:

  • Exercise Physiology
  • Skeletal Muscle Biology
  • Cellular Adaptation

Background:

  • Skeletal muscles exhibit diverse fiber-type compositions.
  • Exercise training induces complex adaptations in muscle tissue.
  • Understanding muscle-specific responses to exercise is crucial.

Purpose of the Study:

  • To evaluate the effects of moderate exercise training on Tibialis Anterior (TA) and Soleus (SOL) muscles.
  • To investigate fiber adaptations, metabolic shifts, and molecular mechanisms.
  • To examine oxidative stress, antioxidant responses, and ion handling.

Main Methods:

  • Moderate treadmill exercise training for 14 weeks in rats.
  • Comparison between trained and sedentary control groups.
  • Analysis of muscle regulatory factors, satellite cell proliferation, and protein expression (desmin, TNFR2, HSP70i).

Main Results:

  • Increased muscle regulatory factors and satellite cell proliferation in both TA and SOL.
  • Moderate hypertrophy in SOL and hyperplasia in TA.
  • TA showed a shift towards oxidative metabolism and increased antioxidant enzymes.
  • HSP70i upregulated in both muscles; oxidative stress markers increased in SOL.
  • Preserved function of ionic channels and pumps.

Conclusions:

  • Exercise-induced ROS increase likely underlies observed adaptations.
  • Muscle-specific responses are evident in fiber type, metabolism, and oxidative stress.
  • Moderate exercise promotes beneficial adaptations while preserving ionic homeostasis.