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Related Concept Videos

Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...

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Related Experiment Video

Updated: May 15, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

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Published on: November 20, 2015

Brain maturation after preterm birth.

Zoltán Molnár1, Mary Rutherford

  • 1Department of Physiology, Anatomy and Genetics, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX, UK. zoltan.molnar@dpag.ox.ac.uk

Science Translational Medicine
|January 18, 2013
PubMed
Summary
This summary is machine-generated.

Premature birth delays cerebral cortex grey matter maturation. Optimizing neonatal care to prevent growth impairment may improve brain development and lessen associated neurological disabilities.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Neonatal Medicine

Background:

  • Premature birth is a significant risk factor for long-term neurological impairments.
  • The developing brain, particularly the cerebral cortex, is vulnerable to insults during the preterm period.
  • Understanding the impact of prematurity on cortical maturation is crucial for improving outcomes.

Purpose of the Study:

  • To investigate the association between premature birth and the maturation of grey matter in the cerebral cortex.
  • To explore whether medical interventions preventing growth impairment in premature neonates can enhance cortical development.
  • To assess the potential of optimized neonatal care in reducing neurological disabilities linked to preterm birth.

Main Methods:

  • Conducted two translational studies: one involving human neonates and another in a sheep model.
  • Utilized neuroimaging and developmental assessments to evaluate cortical grey matter maturation.
  • Monitored neonatal growth parameters and implemented care strategies to prevent growth impairment.

Main Results:

  • Findings indicate a correlation between premature birth and delayed maturation of cerebral cortical grey matter.
  • Evidence suggests that medical care focused on preventing growth impairment positively influences cortical development.
  • Optimized neonatal care demonstrated potential in mitigating neurological deficits associated with preterm birth.

Conclusions:

  • Premature birth adversely affects cerebral cortical grey matter maturation.
  • Preventing growth impairment through neonatal medical care is a promising strategy to enhance brain development.
  • Targeted neonatal interventions hold potential for reducing the burden of neurological disabilities in preterm infants.