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Related Experiment Videos

Coagulation disturbances following ascites recirculation.

J T Wilde1, P Cooper, H J Kennedy

  • 1University Department of Haematology, Royal Hallamshire Hospital, Sheffield, United Kingdom.

Journal of Hepatology
|March 1, 1990
PubMed
Summary
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Extra-corporeal ascites recirculation may cause mild disseminated intravascular coagulation (DIC) in patients with diuretic-resistant ascites. While coagulation changes were observed, they were generally not clinically significant for most patients.

Area of Science:

  • Coagulation science
  • Hepatology
  • Internal medicine

Background:

  • Diuretic-resistant ascites is a common complication in advanced liver disease.
  • Extra-corporeal ascites recirculation is a procedure used to manage refractory ascites.
  • The impact of ascites recirculation on hemostasis requires further investigation.

Purpose of the Study:

  • To evaluate the effects of extra-corporeal ascites recirculation on coagulation parameters.
  • To determine if ascites recirculation induces a pro-coagulant state.

Main Methods:

  • Coagulation variables were measured in plasma and ascitic fluid from 16 patients.
  • Measurements were taken before, during, and after the ascites recirculation procedure.
  • Assessed parameters included fibrinogen, platelet count, X-oligomer, and activated factor VII.

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Main Results:

  • Minor but significant reductions in plasma fibrinogen and platelet counts were noted.
  • Plasma X-oligomer levels increased during and after the procedure.
  • Ascitic fluid showed increased activated factor VII and fibrinolytic activity, indicating coagulation activation and fibrinolysis.

Conclusions:

  • Ascites recirculation may induce mild disseminated intravascular coagulation (DIC).
  • The observed coagulation changes are likely of no major clinical significance for most patients.
  • Ascitic fluid itself exhibits active coagulation and fibrinolysis processes.