Related Experiment Video
Updated: May 15, 2026
12:49
Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
Published on: August 17, 2022
Ex-situ liver surgery without veno-venous bypass
Ke-Ming Zhang1, Xiong-Wei Hu, Jia-Hong Dong
1Department of Hepatobiliary Surgery, 302 Hospital of Chinese People's Liberation Army, Beijing 100039, China.
World Journal of Gastroenterology
|January 18, 2013
Summary
Ex-situ liver resection with hypothermic perfusion offers a viable treatment for complex liver tumors. This technique, performed without veno-venous bypass, shows potential for unresectable hepatic neoplasms.
Area of Science:
- Hepatobiliary Surgery
- Surgical Oncology
- Transplantation Surgery
Background:
- Complex hepatic neoplasms often pose challenges for traditional resection.
- Involvement of major vascular structures necessitates innovative surgical approaches.
Purpose of the Study:
- To evaluate the efficacy of ex-situ liver resection with hypothermic perfusion.
- To assess outcomes of hepatic autotransplantation without veno-venous bypass for unresectable liver tumors.
Main Methods:
- Retrospective analysis of prospectively collected data from 3 patients undergoing ex-situ liver surgery, vein cava replacement, and hepatic autotransplantation.
- Procedures were performed without veno-venous bypass.
- Comparison with existing literature (Pichlmayr's group).
Main Results:
- Successful ex-situ resection and autotransplantation were performed in 3 patients with challenging liver tumors.
- Operation times and anhepatic phases were recorded.
- Survival without recurrence was observed in 2 cases; one case had a fatal complication.
Conclusions:
- Ex-situ liver resection combined with autotransplantation is a promising option for complex hepatic neoplasms.
- This technique can be applied to tumors unresectable by conventional hepatectomy.
- Careful patient selection and surgical expertise are crucial for successful outcomes.
