Related Experiment Video
Updated: May 15, 2026
07:49
Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
Published on: April 13, 2015
Tumor-infiltrating B cells come into vogue
1Division of Molecular Oncology and Immunotherapy, Department of General Surgery, University of Rostock, D-18057 Rostock, Germany. michael.linnebacher@med.uni-rostock.de
World Journal of Gastroenterology
|January 18, 2013
Summary
Tumor-infiltrating B cells, not just T cells, may play a key role in cancer prognosis. This finding has significant implications for cancer research and developing new therapies.
Area of Science:
- Immunology
- Oncology
- Cancer Research
Background:
- Lymphocyte infiltration in solid tumors is linked to better patient outcomes.
- Cytotoxic T cells are traditionally recognized for their role in tumor destruction.
- The immune system's complexity suggests other lymphocytes, like B cells, could be significant.
Purpose of the Study:
- To highlight the potential central role of tumor-infiltrating B cells.
- To discuss the impact of this role on cancer research and treatment.
- To explore future therapeutic concepts based on B cell activity.
Main Methods:
- Commentary article synthesizing recent findings.
- Review of existing literature on tumor immunology.
- Discussion of potential clinical and research implications.
Main Results:
- Recent findings suggest tumor-infiltrating B cells may have a central role in cancer prognosis.
- This role could be as important as that of cytotoxic T cells.
- The impact extends to basic research, prognostics, and therapeutic development.
Conclusions:
- Tumor-infiltrating B cells represent a significant area for future investigation.
- Understanding B cell function in tumors can advance prognostic accuracy.
- Targeting B cells offers a promising avenue for novel cancer therapies.
Keywords:
CD20+ tumor-infiltrating lymphocytesFunctional immunologyImmunotherapyPrognosisTumor-infiltrating B cellsMore Related Videos
Related Concept Videos
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...