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Association analysis of polymorphisms in ROCK2 with cardiovascular disease in a Chinese population

Lei Liu1, Yanyan Cao, Guanglin Cui

  • 1Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Plos One
|January 18, 2013
PubMed

Insights

Common variants in the ROCK2 gene were not significantly associated with coronary artery disease (CAD) risk in the Chinese population. Further large-scale studies are needed to fully evaluate the relationship between ROCK2 polymorphisms and cardiovascular disease. Keywords: ROCK2, coronary artery disease, genetic variants, Chinese population.

Area of Science:

  • Genetics
  • Cardiovascular Disease Research
  • Molecular Biology

Background:

  • Rho-kinase (ROCK) signaling is implicated in cardiovascular diseases like coronary artery disease (CAD) and hypertension.
  • Recent studies suggest ROCK2 gene variants influence blood pressure.
  • The association between ROCK2 variants and cardiovascular disease in the Chinese population remains understudied.

Purpose of the Study:

  • To investigate the relationship between common ROCK2 gene variants and the risk of coronary artery disease (CAD).
  • To analyze genetic association of ROCK2 polymorphisms with CAD in a Chinese cohort.

Main Methods:

  • Screening of common ROCK2 variants via direct sequencing of all exons.
  • Genetic association analysis using a case-control study design.
  • Inclusion of 1344 CAD cases and 1267 matched controls from the Chinese population.

Main Results:

  • No significant association was found between common coding region variants of ROCK2 and CAD risk.
  • Specific variants (rs978906, rs2230774, rs56304104) showed no statistically significant correlation with CAD.
  • Odds ratios (OR) and P-values indicated a lack of association for the tested ROCK2 variants.

Conclusions:

  • The current study did not establish a significant link between common ROCK2 polymorphisms and CAD risk in the studied Chinese population.
  • The potential role of ROCK2 in cardiovascular disease risk cannot be definitively ruled out.
  • Further large-scale population studies are recommended to explore the ROCK2-cardiovascular disease association.
Abstract

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