Related Experiment Video
Updated: May 15, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Overexpression of c-Met in cervical intraepithelial neoplasia
C Comunoğlu1, K Boynukalin, M G Uğur
1Near East University, Faculty of Medicine, Department of Pathology, Nicosia, Turkish Republic of Northern Cyprus, Turkey. cemcomunoglu@gmail.com
Purpose Of Investigation:
The purpose of this study is to evaluate the significance of the c-Met / Hepatocyte Growth Factor Receptor (HGFR) expression in cervical intraepithelial neoplasia (CIN).
Materials And Methods:
Twenty-one patients from two types of cervical intraepithelial neoplasias (LSIL and HSIL), diagnosed in our clinic were studied with c-Met immunohistochemistry. Of the 21 cases, five were diagnosed as LSIL and 16 as HSIL. Normal cervical mucosas from five patients were studied with c-Met as control cases.
Results:
Overexpression of c-Met was found in all five of LSIL specimens. C-Met overexpression was observed in 11 cases of HSIL. No c-Met overexpression was seen in any of the five control cases.
Conclusion:
These results revealed that c-Met oncogene overexpression is an important parameter in cervical early oncogenesis and may have a role in malignant transformation of cervical epithelial cells.
Related Concept Videos
Induced Pluripotent Stem Cells
Somatic cells are...
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Mitogens and the Cell Cycle
Cellular Adaptation IV: Dysplasia and Metaplasia
Cadherins in Tissue Organization
Cell Sorting During Development
Cell sorting plays an...
Abnormal Proliferation
