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Published on: July 17, 2020
Total synthesis of chaetoquadrins A-C
U Bin Kim1, Daniel P Furkert, Margaret A Brimble
1School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland, New Zealand.
Organic Letters
|January 19, 2013
Abstract:
The first total synthesis of the monoamine oxidase inhibitors chaetoquadrins A-C has been accomplished. Key steps in the synthesis include an aromatic Claisen rearrangement, asymmetric boron aldol reaction and acid-mediated spiroketalization. Comparison of spectral data for the synthetic spiroketals confirmed the proposed structure for these natural products.
