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Nonepithelial skin tumors with multinucleated giant cells.
María del Carmen Gómez-Mateo1, Carlos Monteagudo
1Department of Pathology, Hospital Clínico Universitario-INCLIVA, University of Valencia, Valencia, Spain.
Seminars in Diagnostic Pathology
|January 19, 2013
Summary
Identifying multinucleated giant cells in skin tumors aids diagnosis. This review details giant cell types and their associated clinicopathological contexts in nonepithelial cutaneous lesions.
Area of Science:
- Dermatopathology
- Oncology
- Histology
Background:
- Multinucleated giant cells (MGCs) are present in various skin lesions.
- Distinguishing MGC types is crucial for accurate diagnosis of cutaneous tumors.
Purpose of the Study:
- To review and analyze different types of MGCs in nonepithelial cutaneous tumors.
- To correlate MGC morphology with specific clinicopathological contexts for differential diagnosis.
Main Methods:
- Literature review of histopathological findings in nonepithelial cutaneous tumors.
- Analysis of clinicopathological data associated with MGCs.
Main Results:
- Touton giant cells are associated with xanthogranulomas and xanthomas.
- Ground glass giant cells are characteristic of reticulohistiocytomas.
- Osteoclast-like cells appear in giant cell tumors of soft parts and atypical fibroxanthoma.
- Floret-like cells are found in giant cell fibroblastoma and pleomorphic lipoma.
Conclusions:
- Recognizing specific MGC morphologies aids in differentiating neoplastic and pseudotumoral skin lesions.
- Understanding the clinicopathological context of MGCs improves diagnostic accuracy for cutaneous tumors.
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