Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 15, 2026

Dual-modality Molecular Cartography: Integrating Multiplex mRNA Detection with Protein Imaging Mass Cytometry
06:51

Dual-modality Molecular Cartography: Integrating Multiplex mRNA Detection with Protein Imaging Mass Cytometry

Published on: November 14, 2025

Molecular diagnostics complementing morphology in superficial mesenchymal tumors.

Alison L Cheah1, John R Goldblum, Steven D Billings

  • 1Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA.

Seminars in Diagnostic Pathology
|January 19, 2013
PubMed
Summary

Molecular techniques are vital for diagnosing soft tissue tumors with recurring genetic changes. This review highlights mesenchymal tumors with specific abnormalities found in superficial skin layers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CARMN fusions and PDGFRB mutations highlight key differences among cutaneous tumors with myopericytic differentiation.

The Journal of investigative dermatology·2026
Same author

Papillary Squamous Intraepithelial Lesion Outside the Uterine Cervix: Clinicopathological Characterization and Immunohistochemical Study.

The American journal of surgical pathology·2026
Same author

CRTC1::TRIM11 Cutaneous Tumors With Atypia: Melanoma Mimicry, Aggressive Potential, and Methylation Classifier Limitations.

Genes, chromosomes & cancer·2026
Same author

Rare Secondary Neoplasms Arising in Epidermal Nevus: A Case Series and Literature Review.

Journal of cutaneous pathology·2026
Same author

Spitz Melanocytoma With a Novel CPEB2::MAP3K2 Rearrangement: A Case Report.

Journal of cutaneous pathology·2026
Same author

TPM4::ALK Rearranged Cutaneous Epithelioid Vascular Tumor: A Case Report.

Journal of cutaneous pathology·2026

Area of Science:

  • Pathology
  • Oncology
  • Genetics

Background:

  • Molecular techniques are crucial in surgical pathology.
  • Soft tissue tumors often exhibit recurring cytogenetic abnormalities.
  • Understanding these abnormalities enhances tumor knowledge and diagnostic methods.

Purpose of the Study:

  • To review mesenchymal tumors with specific cytogenetic abnormalities.
  • Focus on tumors presenting as superficial dermal or subcutaneous lesions.

Main Methods:

  • Literature review of mesenchymal tumors.
  • Analysis of cytogenetic abnormalities in soft tissue tumors.
  • Focus on diagnostic molecular techniques.

Main Results:

More Related Videos

Isolation of Cells with Morphological and Spatial Information from Oral Submucous Fibrosis Samples by Laser Capture Microdissection
05:42

Isolation of Cells with Morphological and Spatial Information from Oral Submucous Fibrosis Samples by Laser Capture Microdissection

Published on: August 11, 2023

Related Experiment Videos

Last Updated: May 15, 2026

Dual-modality Molecular Cartography: Integrating Multiplex mRNA Detection with Protein Imaging Mass Cytometry
06:51

Dual-modality Molecular Cartography: Integrating Multiplex mRNA Detection with Protein Imaging Mass Cytometry

Published on: November 14, 2025

Isolation of Cells with Morphological and Spatial Information from Oral Submucous Fibrosis Samples by Laser Capture Microdissection
05:42

Isolation of Cells with Morphological and Spatial Information from Oral Submucous Fibrosis Samples by Laser Capture Microdissection

Published on: August 11, 2023

  • Identification of mesenchymal tumors with recurring cytogenetic abnormalities.
  • Correlation of specific genetic changes with tumor types.
  • Emphasis on superficial soft tissue tumors.

    • Conclusions:

    • Cytogenetic abnormalities are key features of many soft tissue tumors.
    • Molecular diagnostics aid in the accurate classification of these tumors.
    • Knowledge of specific abnormalities improves diagnostic accuracy for superficial mesenchymal tumors.