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Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs
Published on: March 5, 2016
Signet ring cell lymphoma with plasmacytic differentiation in a pig
Sumie Nishijo1, Kikumi Ogihara, Yoshiharu Ishikawa
1Yokohama City Meat Inspection Center, 3-53 Daikoku, Tsurumi, Yokohama, Kanagawa 230-0053, Japan.
The Journal of Veterinary Medical Science
|January 19, 2013
Summary
A rare signet ring cell lymphoma case in a sow showed neoplastic cells with features of plasma cells, not typical follicular center B lymphocytes. This suggests abundant immunoglobulin synthesis and defective secretion, impacting lymphoma development.
Area of Science:
- Veterinary Pathology
- Comparative Oncology
- Swine Neoplasia
Background:
- Signet ring cell lymphoma is a rare neoplastic condition.
- Understanding its cellular origin and characteristics is crucial for diagnosis and treatment.
Observation:
- A case of signet ring cell lymphoma in a 3-year-old mixed-breed sow is presented.
- Macroscopic findings included enlarged lymph nodes and liver tumor masses.
- Microscopic examination revealed neoplastic cells with Russell bodies within the rough endoplasmic reticulum (RER).
Findings:
- Immunohistochemistry confirmed Russell bodies stained positive for IgM (κ).
- Ultrastructural analysis showed these bodies as amorphous material within distended RER cisternae.
- Neoplastic cells exhibited plasma cell features, including heterochromatin arrangement and developed RER, differing from typical follicular center B lymphocytes.
Implications:
- The findings suggest abundant immunoglobulin synthesis and defective secretion by neoplastic cells.
- This cellular behavior may contribute to the characteristic signet ring cell morphology.
- The study provides insights into the pathogenesis of signet ring cell lymphoma in swine.
