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Related Experiment Videos

Cutaneous calciphylaxis: a retrospective histopathologic evaluation.

Mark C Mochel1, Ryan Y Arakaki, Guilin Wang

  • 1Department of Pathology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA.

The American Journal of Dermatopathology
|January 19, 2013
PubMed
Summary
This summary is machine-generated.

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Calciphylaxis diagnosis can be challenging. Histologic features like perieccrine calcification and vascular changes, detected by von Kossa and Alizarin red stains, aid in identifying this rare skin disease.

Area of Science:

  • Dermatopathology
  • Vascular Biology
  • Histochemistry

Background:

  • Calciphylaxis is a rare, severe condition causing skin necrosis and vascular calcification.
  • Skin biopsies are often inconclusive for calciphylaxis diagnosis due to specimen limitations.

Purpose of the Study:

  • To evaluate histologic features for diagnosing calciphylaxis.
  • To compare von Kossa and Alizarin red stains for detecting calcium deposits.

Main Methods:

  • Retrospective analysis of 56 calciphylaxis skin biopsies and 19 control biopsies.
  • Evaluation of histologic features and histochemical stain findings (von Kossa, Alizarin red).

Main Results:

  • Vascular calcification and thrombosis strongly correlate with calciphylaxis.

Related Experiment Videos

  • Perieccrine calcium deposition, specific to calciphylaxis, was found in 7% of cases.
  • Alizarin red showed larger, birefringent deposits compared to von Kossa.

    • Conclusions:

    • Subtle perieccrine calcification can aid calciphylaxis diagnosis when typical signs are absent.
    • Using both von Kossa and Alizarin red stains may improve calcium deposit detection in calciphylaxis.