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Updated: May 15, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

Evaluating the management of obstructive sleep apnea in neonates and infants

Rachel L Leonardis1, Jacob G Robison, Todd D Otteson

  • 1Departments of Otolaryngology, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15224, USA. leonardis.rachel@medstudent.pitt.edu

JAMA Otolaryngology-- Head & Neck Surgery
|January 19, 2013
PubMed

Insights

Treatments for infant obstructive sleep apnea (OSA) vary, with anti-gastroesophageal reflux disease medication being most common. Continuous positive airway pressure/bilevel positive airway pressure (CPAP/BiPAP) showed the greatest improvement in apnea-hypopnea index.

Area of Science:

  • Pediatric Pulmonology
  • Sleep Medicine
  • Neonatology

Background:

  • Obstructive sleep apnea (OSA) significantly impacts neonates and infants.
  • Understanding effective interventions is crucial for managing pediatric OSA.

Purpose of the Study:

  • To investigate and report on the efficacy of various interventions for treating OSA in neonates and infants.
  • To analyze intervention patterns across different age groups within the first year of life.

Main Methods:

  • Retrospective review of medical records from a tertiary care children's hospital.
  • Inclusion criteria: neonates and infants (0-12 months) diagnosed with OSA via polysomnography.
  • Data collected included demographics, comorbidities, polysomnography results, and intervention details.

Main Results:

  • 126 patients were analyzed. Anti-gastroesophageal reflux disease treatment was the most frequent intervention (69.8%).
  • Continuous positive airway pressure/bilevel positive airway pressure (CPAP/BiPAP) and tracheostomy demonstrated the greatest objective improvements in apnea-hypopnea index.
  • While adenoidectomy is common overall, supraglottoplasty was most effective in neonates and infants aged 0-3 months.

Conclusions:

  • Anti-gastroesophageal reflux disease treatment is a primary intervention across all age groups.
  • CPAP/BiPAP use is associated with the most significant objective improvement in OSA severity.
  • Surgical interventions like supraglottoplasty show promise for younger infants, while adenoidectomy becomes more prevalent with age.
Abstract

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