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Published on: September 15, 2017
Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implications.
Gilberto Paz-Filho1, Claudio Mastronardi, Carina Bertoldi Franco
1Australian National University, Canberra, Australia. gilberto.pazfilho@anu.edu.au
Arquivos Brasileiros De Endocrinologia E Metabologia
|January 19, 2013
Summary
Leptin regulates immunity and inflammation through its receptor and intracellular pathways like JAK-STAT. This review explores leptin
Area of Science:
- Endocrinology
- Immunology
- Molecular Biology
Background:
- Leptin, an adipokine from white adipose tissue, influences food intake, immunity, and inflammation.
- Leptin deficiency causes immune defects and increased mortality in animal and human models.
- Leptin's receptor is present on various immune cells, mediating its inflammatory effects.
Purpose of the Study:
- To review the molecular mechanisms of leptin in regulating immunity and inflammation.
- To associate these mechanisms with chronic inflammatory disorders.
Main Methods:
- Review of existing literature on leptin signaling pathways.
- Analysis of molecular mechanisms involving JAK-STAT, PI3K, and ERK 1/2 pathways.
- Correlation of leptin's role in immunity with chronic inflammatory conditions.
Main Results:
- Leptin signaling involves JAK-STAT, PI3K, and ERK 1/2 pathways.
- Intracellular proteins modulate leptin's biological activity.
- Leptin's role in immunity and inflammation is linked to chronic disorders.
Conclusions:
- Leptin is a key regulator of immune and inflammatory responses.
- Understanding leptin pathways is crucial for addressing chronic inflammatory diseases.
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