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Genome-wide expression profiling in pediatric septic shock.

Hector R Wong1

  • 1Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center and Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio, USA. hector.wong@cchmc.org

Pediatric Research
|January 19, 2013
PubMed
Summary

This study analyzed gene expression in critically ill children with septic shock, revealing immune system repression and distinct patient subgroups. These findings aid in discovering new treatments and biomarkers for pediatric septic shock.

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Area of Science:

  • Genomics
  • Pediatric critical care
  • Systems biology

Background:

  • A decade-long effort has generated a multicenter, microarray-based, genome-wide expression database for critically ill children (≤10 years) with septic shock.
  • Previous research has focused on discovery-oriented, exploratory analysis of this unique dataset.

Purpose of the Study:

  • To review the diverse applications of this pediatric septic shock gene expression database.
  • To highlight the translation of genomic data into clinical applications.
  • To showcase advancements in understanding pediatric septic shock.

Main Methods:

  • Bioinformatic and systems biology approaches were employed to analyze genome-wide expression data.
  • Microarray-based profiling was utilized to generate comprehensive expression data.

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  • Data mining facilitated the identification of gene expression patterns and subgroups.

    • Main Results:

    • Widespread repression of adaptive immune system gene programs was observed.
    • Significant differential gene expression patterns were identified across developmental age groups.
    • Gene expression-based subclasses of pediatric septic shock with distinct clinical phenotypes were discovered.
    • Novel therapeutic targets, stratification biomarkers, and diagnostic biomarkers were identified.

    Conclusions:

    • Genome-wide expression profiling in pediatric septic shock has yielded significant results over the past decade.
    • The research has transitioned from exploratory discovery to clinical application.
    • The findings provide a foundation for addressing clinical needs in pediatric septic shock through genomic insights.