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Microfluidic Applications for Disposable Diagnostics

Microfluidic Applications for Disposable Diagnostics

Published on: February 3, 2008

Applications of microfluidics for molecular diagnostics.

Harikrishnan Jayamohan¹, Himanshu J Sant, Bruce K Gale

¹Department of Mechanical Engineering, State of Utah Center of Excellence for Biomedical Microfluidics, University of Utah, Salt Lake City, UT, USA.

Methods in Molecular Biology (Clifton, N.J.)

|January 19, 2013

Summary

Microfluidic devices offer rapid, cost-effective diagnostic assays for diseases and pathogens. Future molecular diagnostics will utilize highly multiplexed microfluidic devices for simultaneous screening of numerous conditions.

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Area of Science:

Biomedical Engineering
Molecular Diagnostics
Microfluidics

Background:

Microfluidic devices have seen rapid development for diagnostic assays.
Hundreds of microfluidics-based approaches for clinical diagnostics and pathogen detection exist.
These assays are generally rapid, customizable, and potentially cost-effective.

Purpose of the Study:

To review microfluidics in molecular diagnostics based on application areas.
To provide a concise review of microfluidics in general.
To discuss the transition to polymer-fabricated devices.

Main Methods:

Review of microfluidic principles and microfabrication techniques.
Discussion of polymer-based microfluidic devices.
Categorization of microfluidic diagnostic devices by application area.

Main Results:

Current microfluidic diagnostic devices often target single diseases or pathogens.
A significant market exists for these focused diagnostic devices.
The future trend is towards highly multiplexed microfluidic devices.

Conclusions:

Microfluidics is revolutionizing molecular diagnostics with rapid and cost-effective solutions.
While single-disease devices are prevalent, multiplexed systems represent the future.
Highly multiplexed microfluidic devices will enable simultaneous screening for hundreds of diseases.