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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens
09:15

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens

Published on: May 23, 2014

Somatic stem cells in the human endometrium.

Irene Cervelló1, Aymara Mas, Claudia Gil-Sanchis

  • 1Fundación IVI-Instituto Universitario IVI-Universidad de Valencia, INCLIVA, Paterna, Valencia, Spain. Irene.Cervello@ivi.es

Seminars in Reproductive Medicine
|January 19, 2013
PubMed
Summary
This summary is machine-generated.

Human endometrial stem cells, crucial for tissue regeneration, have been confirmed through recent research. This discovery opens new avenues for treating gynecological diseases and advancing regenerative medicine.

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Last Updated: May 15, 2026

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Published on: May 23, 2014

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Area of Science:

  • Reproductive Biology
  • Stem Cell Biology
  • Gynecology

Background:

  • The concept of human endometrial somatic stem cells emerged mid-20th century, gaining traction between 1978-1989, but definitive evidence was published in 2004.
  • The last eight years have been highly productive, significantly advancing our understanding of endometrial stem cell biology and the endometrium's regenerative capacity.

Purpose of the Study:

  • To summarize current scientific knowledge on endometrial somatic stem cells.
  • To explore their existence, origins, role in pathologies, and potential in regenerative medicine.

Main Methods:

  • Review of scientific literature on endometrial stem cells.
  • Analysis of studies using label-retaining cell methods in murine models.
  • Examination of human endometrial cell isolation techniques.
  • Investigation of bone marrow as a potential extrauterine source.
  • Exploration of biological pathways in pathologies and regenerative medicine applications.

Main Results:

  • Confirmed existence of somatic stem cells in murine and human endometria.
  • Identified bone marrow as a potential extrauterine source of endometrial stem cells.
  • Elucidated the involvement of these cells in endometriosis and endometrial cancer.
  • Highlighted the potential of endometrial stem cells in regenerative medicine, including autologous transplant and bioengineering.

Conclusions:

  • The existence and significance of human endometrial somatic stem cells are now well-established.
  • These cells play a crucial role in endometrial regeneration and are implicated in key gynecological pathologies.
  • Future applications in regenerative medicine, particularly for autologous transplantation and tissue bioengineering, hold significant promise.