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Oxidant/antioxidant system markers and trace element levels in children with nutritional rickets

Murat Doğan1, Yaşar Cesur, Şekibe Zehra Doğan

  • 1Division of Pediatric Endocrinology, Department of Pediatrics, YYU School of Medicine, Van, Turkey. doganmurat.md@gmail.com

Journal of Pediatric Endocrinology & Metabolism : JPEM
|January 19, 2013
PubMed

Insights

Nutritional rickets in children is linked to increased oxidative stress and lower antioxidant defenses. Vitamin D treatment significantly reduces oxidative stress and improves the antioxidant system in these patients.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Nutritional Science

Background:

  • Nutritional rickets, a condition linked to vitamin D deficiency, affects bone health in children.
  • Oxidative stress and trace element imbalances are implicated in various pediatric diseases.

Purpose of the Study:

  • To investigate in vivo oxidative stress and trace element levels in children with nutritional rickets.
  • To assess the impact of vitamin D treatment on these parameters.

Main Methods:

  • Studied 30 children with nutritional rickets and 30 healthy controls.
  • Measured serum levels of calcium, phosphorus, alkaline phosphatase, parathormone, and 25-OH vitamin D.
  • Assessed oxidant/antioxidant markers (vitamin C, beta-carotene, glutathione, superoxide dismutase, MDA) and trace elements (zinc) pre- and post-treatment.

Main Results:

  • Patients with rickets showed significantly altered serum biochemistry and lower pretreatment zinc levels compared to controls.
  • Pretreatment analysis revealed higher oxidative stress markers (MDA) and lower antioxidant markers (vitamin C, beta-carotene, glutathione, superoxide dismutase) in rickets patients.
  • Vitamin D treatment led to reduced oxidative stress and improved antioxidant system markers.

Conclusions:

  • Nutritional rickets is associated with heightened oxidative stress and a compromised antioxidant defense system.
  • Vitamin D supplementation effectively mitigates oxidative stress and enhances antioxidant capacity in children with rickets.
Abstract

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