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Related Concept Videos

Regulation of Food Intake01:30

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
Primary Motives: Hunger and Thirst01:25

Primary Motives: Hunger and Thirst

Hunger and thirst are fundamental physiological drives crucial for maintaining homeostasis and ensuring the survival of both humans and animals. These drives are regulated through complex interactions between the brain, hormones, and sensory receptors.
Hunger arises when the brain detects changes in the body's nutrient levels, including glucose, lipids, amino acids, and hormones such as ghrelin and leptin. The hypothalamus plays a central role in hunger regulation. The lateral hypothalamus acts...

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Updated: May 15, 2026

Quantifying Food Intake in Caenorhabditis elegans by Measuring Bacterial Clearance
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Published on: February 23, 2024

Appetite Control: worm's-eye-view.

Young-Jai You1, Leon Avery

  • 1Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia.

Animal Cells and Systems
|January 19, 2013
PubMed
Summary
This summary is machine-generated.

Animal appetite control involves complex signals influencing feeding behaviors. This review explores conserved molecular mechanisms of hunger and satiety, using the model organism C. elegans to understand appetite genetics.

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Area of Science:

  • Neuroscience
  • Genetics
  • Animal Behavior

Background:

  • Food intake regulation is crucial for animal survival and involves distinct hunger and satiety behaviors.
  • Appetite control is influenced by nutritional status, experience, and environment, with dysregulation contributing to diseases like obesity.
  • Understanding the genetic basis of appetite control is limited due to a lack of simple genetic model systems.

Purpose of the Study:

  • To review current knowledge on molecular and cellular mechanisms of food intake regulation.
  • To highlight the conserved nature of hunger and satiety signaling pathways.
  • To explore the utility of *C. elegans* as a model system for studying the genetics of appetite control.

Main Methods:

  • Literature review of molecular and cellular mechanisms governing food intake.
  • Focus on less-understood muscarinic and cyclic guanosine monophosphate (cGMP) signaling pathways.
  • Comparative analysis of conserved hunger and satiety mechanisms in *C. elegans*.

Main Results:

  • Hunger drives food seeking and consumption, while satiety promotes rest and cessation of feeding.
  • Molecular and cellular signals mediate these opposing behavioral states.
  • Key signaling pathways, including muscarinic and cGMP, are conserved across species.

Conclusions:

  • *C. elegans* offers a valuable genetic model for dissecting the complex mechanisms of appetite control.
  • Investigating conserved pathways in simpler organisms can illuminate human metabolic disorders.
  • Further research in *C. elegans* can advance our understanding of the genetic underpinnings of appetite regulation.