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[Cytomegalovirus infection in infants with perinatal damage of the central nervous system]

T T Batysheva, I N Paskhina, I A Pshemyskaia

    Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
    |January 19, 2013
    PubMed

    Insights

    Cytomegalovirus (CMV) DNA was detected in nearly 19% of infants with perinatal central nervous system damage. This viral activity may worsen neurological symptoms, necessitating early CMV testing and antiviral treatment.

    Area of Science:

    • Virology
    • Pediatric Neurology
    • Infectious Diseases

    Background:

    • Infants with perinatal central nervous system (CNS) damage require thorough etiological investigation.
    • Cytomegalovirus (CMV) is a potential opportunistic pathogen in immunocompromised individuals and neonates.

    Observation:

    • A virological study was conducted on 90 infants (7 days to 12 months) with perinatal CNS damage.
    • CMV DNA persistence was identified in blood, urine, and oropharyngeal swabs of 18.9% of the children.
    • CMV DNA was exclusively found in oropharyngeal swabs and urine in 14.4% of cases.

    Findings:

    • The presence of CMV DNA in blood was associated with neurological symptom severity.
    • CMV infection may contribute to increased blood-brain barrier permeability.
    • Absence of positive treatment response in some cases could be linked to active CMV infection.

    Implications:

    • A comprehensive immunological and molecular survey is recommended for infants with suspected CMV infection.
    • Early detection of CMV DNA warrants prompt initiation of specific antiviral therapy.
    • Understanding CMV's role in CNS damage can guide pediatric neurological care and treatment strategies.

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