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Related Experiment Video

Updated: May 15, 2026

A Structured Approach to Extubation in Mechanically Ventilated Rats

A Structured Approach to Extubation in Mechanically Ventilated Rats

Published on: July 18, 2025

Extubation after anaesthesia: a randomised comparison of three techniques.

Peter B Richardson¹, Sunil Krishnan, Chitra Janakiraman

¹University Hospital of Wales, Cardiff, U.K.

Acta Clinica Croatica

|January 22, 2013

Summary

Pressure support ventilation may reduce cough severity during awake extubation. This randomized trial compared ventilation modes, finding pressure support ventilation offered advantages over spontaneous and intermittent positive pressure ventilation.

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Area of Science:

Anesthesiology
Critical Care Medicine
Respiratory Therapy

Background:

The optimal ventilation strategy for awake extubation remains uninvestigated.
Peri-extubation complications can impact patient recovery after anesthesia.

Purpose of the Study:

To compare spontaneous respiration, intermittent positive pressure ventilation, and pressure support ventilation during awake extubation.
To evaluate the incidence and severity of peri-extubation complications across different ventilation modes.

Main Methods:

A randomized controlled trial involving 39 patients undergoing elective surgery.
Patients were assigned to spontaneous respiration, intermittent positive pressure ventilation, or pressure support ventilation (n=13 each) for awake extubation.
Complications and hemodynamic parameters were monitored.

Main Results:

Pressure support ventilation significantly reduced the severity of peri-extubation cough (p=0.049).
Intermittent positive pressure ventilation resulted in the lowest mean arterial pressure at extubation (p=0.007).
No significant differences were observed in other complications or time to extubation.

Conclusions:

Pressure support ventilation may be advantageous for awake extubation, potentially minimizing cough severity.
Further research is warranted to confirm these findings and optimize extubation strategies.