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Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
Published on: November 15, 2013
Nuclear receptors in herb-drug interactions
1Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.
Drug Metabolism Reviews
|January 22, 2013
Summary
Herbal supplements can cause herb-drug interactions (HDIs) by affecting nuclear receptors (NRs). These interactions are complex due to multiple compounds in herbs and individual patient factors.
Area of Science:
- Pharmacology
- Natural Products Chemistry
- Toxicology
Background:
- Herbal supplements are widely used, increasing the risk of herb-drug interactions (HDIs).
- Herb-drug interactions can occur through pharmacokinetic and pharmacodynamic mechanisms.
- Nuclear receptors (NRs) are key regulators of cellular processes and have a defined role in drug interactions.
Purpose of the Study:
- To explore the role of nuclear receptors (NRs) in mediating herb-drug interactions (HDIs).
- To highlight the complexity of NR-mediated HDIs due to the poly-herbal nature of supplements.
Main Methods:
- Review of existing literature on herb-drug interactions and nuclear receptor activation.
- Analysis of pharmacokinetic and pharmacodynamic pathways involved in NR-mediated HDIs.
- Identification of factors influencing the outcomes of NR-mediated HDIs.
Main Results:
- Numerous herbs activate NRs, leading to significant HDIs.
- NR-mediated HDIs are more complex than drug-drug interactions due to the presence of multiple active compounds in herbs.
- Factors such as dosage, timing, patient gender, age, and genetics can influence HDI outcomes.
Conclusions:
- Nuclear receptors play a critical role in herb-drug interactions.
- Understanding NR-mediated HDIs is crucial for ensuring the safe use of herbal supplements alongside conventional drugs.
- Personalized approaches considering patient-specific factors are necessary to manage NR-mediated HDIs effectively.
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