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Updated: May 15, 2026

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
Published on: July 28, 2022
Enantioselective total syntheses and absolute configuration of JBIR-02 and Mer-A2026B
Johannes Hoecker1, Karl Gademann
1Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland.
Abstract:
The first total syntheses of the piericidin related natural products Mer-A2026B and JBIR-02 are reported. Key features of the synthetic approach involve an Ir-catalyzed one-pot C-H activation/oxidation procedure for the preparation of the hydroxypyridine, a vinylogous Mukaiyama aldol reaction, and a final Negishi cross-coupling of an advanced pyridine derivative with an allylic side chain precursor. In addition, the absolute configuration of Mer-A2026B (9R,10R) and JBIR-02 (9R,10R) was established.
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