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Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Patterns of Fever01:26

Patterns of Fever

Before understanding the types and patterns of fever, it is essential to know its phases.
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Types of Fever01:25

Types of Fever

Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...

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Related Experiment Video

Updated: May 15, 2026

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
06:29

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 1, 2011

Unexplained recurrent fever: when is autoinflammation the explanation?

T Kallinich1, M Gattorno, C E Grattan

  • 1Autoinflammation Reference Center Charité (ARC(2)), Charité University Medicine Berlin, Berlin, Germany. tilmann.kallinich@charite.de

Allergy
|January 22, 2013
PubMed
Summary

Recurrent fever can signal various diseases. This review highlights autoinflammatory diseases, offering key features to differentiate them from other febrile illnesses for targeted diagnosis and treatment.

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Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
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Published on: May 16, 2016

Related Experiment Videos

Last Updated: May 15, 2026

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
06:29

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 1, 2011

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
07:48

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation

Published on: May 16, 2016

Area of Science:

  • Internal Medicine
  • Genetics and Genomics
  • Rheumatology

Background:

  • Recurrent fever is a common presenting symptom for diverse medical conditions.
  • The differential diagnosis for recurrent fever is broad, lacking established clinical guidelines.
  • Autoinflammatory diseases (AIDs) are a newly recognized group often presenting with recurrent fevers.

Purpose of the Study:

  • To review diseases commonly presenting with recurrent fever.
  • To summarize characteristic disease presentations.
  • To identify key features distinguishing autoinflammatory diseases from other causes of fever.

Main Methods:

  • Literature review of disease entities associated with recurrent fever.
  • Analysis of symptom patterns in various febrile illnesses.
  • Comparative analysis of autoinflammatory diseases versus other fever causes.

Main Results:

  • Identified common disease categories including malignancies, autoimmune diseases, infections, and AIDs.
  • Detailed characteristic presentations for each disease category.
  • Highlighted specific clinical and laboratory features aiding in the diagnosis of AIDs.

Conclusions:

  • Recognizing distinct symptom patterns is crucial for diagnosing recurrent fever.
  • Differentiating autoinflammatory diseases requires careful analysis of clinical presentations.
  • Identifying AIDs facilitates targeted diagnostic workups and therapeutic interventions.