Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Behavioral antagonism between lead and cadmium.

J R Nation1, C A Grover, G R Bratton

  • 1Department of Psychology, Texas A & M University, College Station 77843.

Neurotoxicology and Teratology
|March 1, 1990
PubMed
Summary

Lead and cadmium exposure in rats had opposing effects on behavior, with cotreatment resulting in no significant changes compared to controls. Metal residue data suggest central interactions influencing behavioral outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dyskeratosis congenita: natural history of the disease through the study of a cohort of patients diagnosed in childhood.

Frontiers in pediatrics·2023
Same author

Late-onset neutropenia: defining limits of neutrophil count in very low birth weight infants.

Journal of perinatology : official journal of the California Perinatal Association·2013
Same author

Enteric dysganglionosis resembling intestinal neuronal dysplasia in a foal with bacterial colitis.

Veterinary pathology·2010
Same author

Dose-dependent attenuation of heroin self-administration with lobeline.

Journal of psychopharmacology (Oxford, England)·2010
Same author

Development and usefulness of an instrument for the standard description and comparison of services for disabilities (DESDE).

Acta psychiatrica Scandinavica. Supplementum·2006
Same author

A neural network underlying individual differences in emotion and aggression in male golden hamsters.

Neuroscience·2004

Area of Science:

  • Environmental toxicology
  • Neurotoxicology
  • Behavioral neuroscience

Background:

  • Lead and cadmium are common environmental contaminants with known toxic effects.
  • Understanding the interactive toxicity of co-exposed metals is crucial for risk assessment.

Purpose of the Study:

  • To investigate the individual and combined effects of lead and cadmium exposure on rat behavior and tissue metal accumulation.
  • To determine if lead and cadmium exposure interact antagonistically or additively.

Main Methods:

  • Adult male rats were fed diets with lead (500 ppm), cadmium (100 ppm), both, or neither for 60 days.
  • Behavioral activity was assessed using a Digiscan activity monitor.
  • Blood and brain metal concentrations were analyzed post-exposure.

Related Experiment Videos

Main Results:

  • Lead alone increased movement and vertical activity; cadmium alone decreased movement and increased rest.
  • Combined lead-cadmium exposure did not significantly alter behavior compared to controls, suggesting antagonism.
  • Blood lead levels were lower with co-exposure, but brain lead levels were similar.
  • Body weight reduction was additive for lead and cadmium, indicating complex interactions.

Conclusions:

  • Lead and cadmium exhibit antagonistic effects on behavior, with one metal's impact being counteracted by the other.
  • Residue data support a central interaction model for lead/cadmium effects on behavior.
  • The toxic effects of lead and cadmium can be either antagonized or augmented by co-treatment depending on the outcome measured.