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Published on: April 28, 2016
Ghrelin, acylated ghrelin, leptin and PYY-3 levels in hyperemesis gravidarum
Mustafa Albayrak1, Ahmet Karatas, Yavuz Demiraran
1Department of and Obstetrics and Gynecology, Duzce University School of Medicine, Duzce, Turkey. drmustalbayrak@yahoo.com
Objective:
To assess the serum levels of gut and adipocyte-derived metabolic hormones that control appetite, adipocity, weight gain and energy hemostasis, namely total ghrelin (TG), acylated ghrelin (AG), leptin and PYY-3 in hyperemesis gravidarum (HG).
Methods:
Plasma samples of 86 women in their first trimester pregnancies with HG (n = 30), morning sickness of pregnancy (MSP) (n = 34) and control (n = 22) groups were obtained. Serum levels of TG, AG, leptin and PYY-3 were compared between the groups, and the correlations with severity of symptoms using modified PUQE (Pregnancy Unique Quantification of Emesis) scoring, BMI, E2, hCG and TSH were calculated.
Results:
Levels of TG, AG, PYY-3 and the TG/leptin ratio were significantly higher in HG group compared to MSP and the control groups (p ≤ 0.017). AG/TG ratio was significantly lower in the HG group compared to both MSP and control groups (p ≤ 0.017). There were either weak or no significant statistical correlations between the gut and adipose-related hormones and the modified PUQE scores, BMI, E2, hCG and TSH.
Conclusion:
Gut-derived metabolic hormones ghrelin, AG and PYY-3 may be involved in the HG pathophysiology.
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